More often than not, the benefit of most supplements overlaps. As a result of this, it becomes a little bit difficult to clearly define what a particular compound can do or cannot do. Lately, there has been a huge discussion on whether polyphenols can help protect the human body from cardiovascular diseases or not.
This article is a review of the possible benefits of polyphenols on the heart, how it works to aid the cardiovascular organs and how you can take advantage of this compound to improve your cardiovascular health. My aim is to discuss the overwhelming research that has been conducted on the benefits of polyphenols and to lay emphasis on why it is important to get enough of this compound to support your body antioxidant system. Polyphenols supplements, as well as natural sources such as grape, vegetable and nuts, are a good place to source for polyphenols in your diet.
First, it is important to emphasize the fact that polyphenols are chiefly antioxidant substance. Which means they’re capable of clearing out free radicals from the cells. Free radicals are the “bad guys” responsible for aging, as well as cell integrity deterioration, resulting in various diseases. What this implies is that any compound that is capable of ridding the body of this free radical is considered highly beneficial.
Since we’ve been able to establish that polyphenols are generally beneficial to the body as an antioxidant compound, let’s check how they can specifically help in protecting the heart from various cardiovascular diseases.
A 2010 research conducted by researchers from Heine University in Germany and King Saud University in Saudi Arabia, the role of polyphenols were examined, using biomarkers such as flow-mediated-dilation (FMD) to access the cardiovascular system, it was discovered that metabolites of polyphenols were consistently active in relation to the FMD.
In a similar research, conducted my scientist from Australia, the polyphenols present in grape were examined, to check the possible cardioprotective actions. Active component from grapes such as the skin, juice as well as the seed was shown to have a certain amount of polyphenols in different varieties, and it was concluded that these compounds are capable of exhibiting antiatherosclerotic, antiarrhythmic and vasorelaxation properties. All of which points to the cardioprotective function of polyphenols in general. It was therefore concluded that grape and grape extract may be beneficial in preventing the emergence of cardiovascular diseases.
It has since been shown that most cardiovascular diseases and underlined by vascular endothelial cells dysfunction. Scientists from Japan, therefore, embarked on a research to check how dietary polyphenols regulates endothelial function and equally prevent cardiovascular disease. In the in vitro experiment, the findings of this research support the hypothesis that polyphenols can help prevent cardiovascular diseases by functioning as an antioxidant in endothelial cells. The scientists, however, noted that in vivo experimental work might produce a different result as compared to in vitro, considering other variables involved.
Summarily, aside from acting as an antioxidant in endothelial cells, it is also known that polyphenols have vasodilatory effects on blood vessels, causing relaxation of the vessel when necessary, and it has also been associated with the reducing oxidation of low-density lipoproteins. A larger percentage of the effect of polyphenols can be explained by the antioxidant mechanism. The diverse ways in which they work is a little bit difficult to explain because polyphenols come in varying forms, and each of these forms has it’s own pathway and mechanism of action.
What matters most, however, is that they’re all capable of producing one or more of the following effects; vasodilation, antiatherogenic effect, antithrombotic effect, and anti-inflammatory effect, all of which are directly related to a healthy cardiovascular system.